Does Estradiol Interact With Gabapentin?
Oral Contraceptive Based on AUC and half-life, multiple-dose pharmacokinetic profiles of norethindrone and ethinyl estradiol following administration of tablets containing 2.5 mg of norethindrone acetate and 50 mcg of ethinyl estradiol were similar with and without coadministration of gabapentin (400 mg three times a day; N=13).
Severity: Minor
Severity basis: drug interactions section. Combining Estradiol (Estrogen) and Gabapentin (Gabapentinoid anticonvulsant) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Estradiol is a estrogen and Gabapentin is a gabapentinoid anticonvulsant; together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Estradiol and Gabapentin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Oral Contraceptive Based on AUC and half-life, multiple-dose pharmacokinetic profiles of norethindrone and ethinyl estradiol following administration of tablets containing 2.5 mg of norethindrone acetate and 50 mcg of ethinyl estradiol were similar with and without coadministration of gabapentin (400 mg three times a day; N=13).
Source: FDA structured product labeling (set_id 01b810b7-f4c8-4412-bbc5-b9220d8770d8).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Estradiol and Gabapentin together?
Estradiol and Gabapentin have a documented minor interaction. This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How serious is the Estradiol and Gabapentin interaction?
It is classified as a minor interaction, based on the FDA label's drug interactions section. A minor interaction is usually limited in effect but is still worth discussing with your care team.
What should I do if I'm taking both Estradiol and Gabapentin?
If you have been prescribed both Estradiol and Gabapentin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Estradiol Interactions
Other Gabapentin Interactions
- Gabapentin + Buprenorphine Naloxone(moderate)
- Gabapentin + Hydrocodone Acetaminophen(moderate)
- Gabapentin + Morphine(moderate)
- Gabapentin + Oxycodone(moderate)
- Gabapentin + Carbamazepine(minor)
- Gabapentin + Codeine(minor)
- Gabapentin + Naproxen(minor)
- Gabapentin + Phenytoin(minor)
- Gabapentin + Tramadol(minor)
- Gabapentin + Valproic Acid(minor)