Does Carbamazepine Interact With Hydrocodone Acetaminophen?

Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in hydrocodone bitartrate and acetaminophen tablets-treated patients may increase hydrocodone plasma concentrations and prolong opioid adverse reactions.

Severity: Moderate

Severity basis: warnings section (keywords: may increase). Combining Carbamazepine (Anticonvulsant) and Hydrocodone Acetaminophen (Opioid analgesic combination) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in hydrocodone bitartrate and acetaminophen tablets-treated patients may increase hydrocodone plasma concentrations and prolong opioid adverse reactions.

Source: FDA structured product labeling (set_id ee248dfd-7aa7-7dcc-e053-2995a90af19f).

Carbamazepine

Anticonvulsant

Brands: Tegretol, Carbatrol

View Carbamazepine safety profile

Hydrocodone Acetaminophen

Opioid analgesic combination

Brands: Norco, Vicodin, Lortab

View Hydrocodone Acetaminophen safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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