Does Hydrocodone Acetaminophen Interact With Rifampin?
Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in hydrocodone bitartrate and acetaminophen tablets-treated patients may increase hydrocodone plasma concentrations and prolong opioid adverse reactions.
Severity: Moderate
Severity basis: warnings section (keywords: may increase). Combining Hydrocodone Acetaminophen (Opioid analgesic combination) and Rifampin (Rifamycin antibiotic (strong CYP3A4 inducer)) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in hydrocodone bitartrate and acetaminophen tablets-treated patients may increase hydrocodone plasma concentrations and prolong opioid adverse reactions.
Source: FDA structured product labeling (set_id ee248dfd-7aa7-7dcc-e053-2995a90af19f).
Hydrocodone Acetaminophen
Opioid analgesic combination
Brands: Norco, Vicodin, Lortab
View Hydrocodone Acetaminophen safety profileCheck these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Hydrocodone Acetaminophen Interactions
Other Rifampin Interactions
- Rifampin + Apixaban(major)
- Rifampin + Clopidogrel(major)
- Rifampin + Dabigatran(major)
- Rifampin + Doxycycline(major)
- Rifampin + Edoxaban(major)
- Rifampin + Fluconazole(major)
- Rifampin + Itraconazole(major)
- Rifampin + Ketoconazole(major)
- Rifampin + Lansoprazole(major)
- Rifampin + Phenytoin(major)
- Rifampin + Rivaroxaban(major)
- Rifampin + Ticagrelor(major)
- Rifampin + Warfarin(major)
- Rifampin + Atorvastatin(moderate)
- Rifampin + Carvedilol(moderate)
- Rifampin + Clarithromycin(moderate)
- Rifampin + Cyclosporine(moderate)
- Rifampin + Eszopiclone(moderate)
- Rifampin + Gemfibrozil(moderate)
- Rifampin + Glimepiride(moderate)
- Rifampin + Glipizide(moderate)
- Rifampin + Methylprednisolone(moderate)
- Rifampin + Mirtazapine(moderate)
- Rifampin + Oxycodone(moderate)
- Rifampin + Pioglitazone(moderate)
- Rifampin + Tacrolimus(moderate)
- Rifampin + Tramadol(moderate)
- Rifampin + Zolpidem(moderate)
- Rifampin + Aripiprazole(minor)
- Rifampin + Buprenorphine Naloxone(minor)
- Rifampin + Canagliflozin(minor)
- Rifampin + Carbamazepine(minor)
- Rifampin + Carbidopa Levodopa(minor)
- Rifampin + Celecoxib(minor)
- Rifampin + Codeine(minor)
- Rifampin + Dapagliflozin(minor)
- Rifampin + Dexamethasone(minor)
- Rifampin + Diazepam(minor)
- Rifampin + Digoxin(minor)
- Rifampin + Diltiazem(minor)
- Rifampin + Enalapril(minor)
- Rifampin + Glyburide(minor)
- Rifampin + Hydroxychloroquine(minor)
- Rifampin + Lamotrigine(minor)
- Rifampin + Levothyroxine(minor)
- Rifampin + Liothyronine(minor)
- Rifampin + Losartan(minor)
- Rifampin + Metoprolol(minor)
- Rifampin + Morphine(minor)
- Rifampin + Nifedipine(minor)
- Rifampin + Nortriptyline(minor)
- Rifampin + Olanzapine(minor)
- Rifampin + Ondansetron(minor)
- Rifampin + Prednisolone(minor)
- Rifampin + Propranolol(minor)
- Rifampin + Quetiapine(minor)
- Rifampin + Simvastatin(minor)
- Rifampin + Tadalafil(minor)
- Rifampin + Trazodone(minor)
- Rifampin + Valproic Acid(minor)
- Rifampin + Verapamil(minor)