Does Bupropion Interact With Cyclobenzaprine?
WARNINGS Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with cyclobenzaprine hydrochloride when used in combination with other drugs, such as selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tramadol, bupropion, meperidine, verapamil, or (MAO) inhibitors.
Severity: Minor
Severity basis: warnings section. Combining Bupropion (Aminoketone antidepressant) and Cyclobenzaprine (Skeletal muscle relaxant) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Bupropion is a aminoketone antidepressant and Cyclobenzaprine is a skeletal muscle relaxant; together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Bupropion and Cyclobenzaprine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
WARNINGS Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with cyclobenzaprine hydrochloride when used in combination with other drugs, such as selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tramadol, bupropion, meperidine, verapamil, or (MAO) inhibitors.
Source: FDA structured product labeling (set_id 00b20a8c-debd-e930-e063-6394a90a7ed0).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Bupropion and Cyclobenzaprine together?
Bupropion and Cyclobenzaprine have a documented minor interaction. This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How serious is the Bupropion and Cyclobenzaprine interaction?
It is classified as a minor interaction, based on the FDA label's warnings section. A minor interaction is usually limited in effect but is still worth discussing with your care team.
What should I do if I'm taking both Bupropion and Cyclobenzaprine?
If you have been prescribed both Bupropion and Cyclobenzaprine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Bupropion Interactions
- Bupropion + Carbamazepine(moderate)
- Bupropion + Carbidopa Levodopa(minor)
- Bupropion + Clopidogrel(minor)
- Bupropion + Codeine(minor)
- Bupropion + Fluoxetine(minor)
- Bupropion + Metoprolol(minor)
- Bupropion + Nortriptyline(minor)
- Bupropion + Paroxetine(minor)
- Bupropion + Phenytoin(minor)
- Bupropion + Risperidone(minor)
- Bupropion + Sertraline(minor)
- Bupropion + Tramadol(minor)
- Bupropion + Varenicline(minor)
- Bupropion + Venlafaxine(minor)