Does Bupropion Interact With Cyclobenzaprine?
WARNINGS Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with cyclobenzaprine hydrochloride when used in combination with other drugs, such as selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tramadol, bupropion, meperidine, verapamil, or (MAO) inhibitors.
Severity: Minor
Severity basis: warnings section. Combining Bupropion (Aminoketone antidepressant) and Cyclobenzaprine (Skeletal muscle relaxant) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
WARNINGS Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with cyclobenzaprine hydrochloride when used in combination with other drugs, such as selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tramadol, bupropion, meperidine, verapamil, or (MAO) inhibitors.
Source: FDA structured product labeling (set_id 00b20a8c-debd-e930-e063-6394a90a7ed0).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Bupropion Interactions
- Bupropion + Carbamazepine(moderate)
- Bupropion + Carbidopa Levodopa(minor)
- Bupropion + Clopidogrel(minor)
- Bupropion + Codeine(minor)
- Bupropion + Fluoxetine(minor)
- Bupropion + Metoprolol(minor)
- Bupropion + Nortriptyline(minor)
- Bupropion + Paroxetine(minor)
- Bupropion + Phenytoin(minor)
- Bupropion + Risperidone(minor)
- Bupropion + Sertraline(minor)
- Bupropion + Tramadol(minor)
- Bupropion + Varenicline(minor)
- Bupropion + Venlafaxine(minor)