Does Celecoxib Interact With Indomethacin?

NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.

Severity: Major

Severity basis: drug interactions section (keywords: avoid). Combining Celecoxib (COX-2 selective NSAID) and Indomethacin (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.

Source: FDA structured product labeling (set_id 00e67d5e-df6f-4dfd-8c2d-a001c8a99af0).

Celecoxib

COX-2 selective NSAID

Brands: Celebrex

View Celecoxib safety profile

Indomethacin

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Indocin

View Indomethacin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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