Does Enalapril Interact With Indomethacin?

In a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving enalapril maleate.

Severity: Minor

Severity basis: drug interactions section. Combining Enalapril (ACE inhibitor) and Indomethacin (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

In a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving enalapril maleate.

Source: FDA structured product labeling (set_id 074fe718-88d8-365c-e063-6394a90a299d).

Enalapril

ACE inhibitor

Brands: Vasotec

View Enalapril safety profile

Indomethacin

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Indocin

View Indomethacin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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