Does Enalapril Interact With Indomethacin?
In a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving enalapril maleate.
Severity: Minor
Severity basis: drug interactions section. Combining Enalapril (ACE inhibitor) and Indomethacin (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Enalapril is a ace inhibitor and Indomethacin is a nonsteroidal anti-inflammatory drug (nsaid); together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Enalapril and Indomethacin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
In a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving enalapril maleate.
Source: FDA structured product labeling (set_id 074fe718-88d8-365c-e063-6394a90a299d).
Indomethacin
Nonsteroidal anti-inflammatory drug (NSAID)
Brands: Indocin
View Indomethacin safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Enalapril and Indomethacin together?
Enalapril and Indomethacin have a documented minor interaction. This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How serious is the Enalapril and Indomethacin interaction?
It is classified as a minor interaction, based on the FDA label's drug interactions section. A minor interaction is usually limited in effect but is still worth discussing with your care team.
What should I do if I'm taking both Enalapril and Indomethacin?
If you have been prescribed both Enalapril and Indomethacin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Enalapril Interactions
Other Indomethacin Interactions
- Indomethacin + Aspirin(contraindicated)
- Indomethacin + Celecoxib(major)
- Indomethacin + Diclofenac(major)
- Indomethacin + Naproxen(major)
- Indomethacin + Atenolol(moderate)
- Indomethacin + Cyclosporine(moderate)
- Indomethacin + Furosemide(moderate)
- Indomethacin + Methotrexate(moderate)
- Indomethacin + Propranolol(moderate)
- Indomethacin + Warfarin(moderate)
- Indomethacin + Dexamethasone(minor)
- Indomethacin + Digoxin(minor)
- Indomethacin + Lithium(minor)
- Indomethacin + Meloxicam(minor)
- Indomethacin + Ramipril(minor)