Does Atenolol Interact With Indomethacin?

Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers.

Severity: Moderate

Severity basis: drug interactions section (keywords: may decrease). Combining Atenolol (Beta-blocker) and Indomethacin (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers.

Source: FDA structured product labeling (set_id 09b21985-1818-449d-9b29-98f733cf7b9f).

Atenolol

Beta-blocker

Brands: Tenormin

View Atenolol safety profile

Indomethacin

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Indocin

View Indomethacin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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