Does Indomethacin Interact With Propranolol?
Administration of indomethacin with propranolol may reduce the efficacy of propranolol in reducing blood pressure and heart rate.
Severity: Moderate
Severity basis: drug interactions section (keywords: may reduce). Combining Indomethacin (Nonsteroidal anti-inflammatory drug (NSAID)) and Propranolol (Beta-blocker) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Indomethacin is a nonsteroidal anti-inflammatory drug (nsaid) and Propranolol is a beta-blocker; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Indomethacin and Propranolol, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Administration of indomethacin with propranolol may reduce the efficacy of propranolol in reducing blood pressure and heart rate.
Source: FDA structured product labeling (set_id 013a485a-4227-46ae-b19f-c550302fcb96).
Indomethacin
Nonsteroidal anti-inflammatory drug (NSAID)
Brands: Indocin
View Indomethacin safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Indomethacin and Propranolol together?
Indomethacin and Propranolol have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Indomethacin and Propranolol interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: may reduce). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Indomethacin and Propranolol?
If you have been prescribed both Indomethacin and Propranolol, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Indomethacin Interactions
- Indomethacin + Aspirin(contraindicated)
- Indomethacin + Celecoxib(major)
- Indomethacin + Diclofenac(major)
- Indomethacin + Naproxen(major)
- Indomethacin + Atenolol(moderate)
- Indomethacin + Cyclosporine(moderate)
- Indomethacin + Furosemide(moderate)
- Indomethacin + Methotrexate(moderate)
- Indomethacin + Warfarin(moderate)
- Indomethacin + Dexamethasone(minor)
- Indomethacin + Digoxin(minor)
- Indomethacin + Enalapril(minor)
- Indomethacin + Lithium(minor)
- Indomethacin + Meloxicam(minor)
- Indomethacin + Ramipril(minor)
Other Propranolol Interactions
- Propranolol + Amiodarone(minor)
- Propranolol + Celecoxib(minor)
- Propranolol + Clonidine(minor)
- Propranolol + Diltiazem(minor)
- Propranolol + Finasteride(minor)
- Propranolol + Levothyroxine(minor)
- Propranolol + Liothyronine(minor)
- Propranolol + Lovastatin(minor)
- Propranolol + Meloxicam(minor)
- Propranolol + Modafinil(minor)
- Propranolol + Naproxen(minor)
- Propranolol + Ramipril(minor)
- Propranolol + Rifampin(minor)
- Propranolol + Verapamil(minor)
- Propranolol + Warfarin(minor)