Does Ciprofloxacin Interact With Cyclosporine?

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Ciprofloxacin is a fluoroquinolone antibiotic and Cyclosporine is a calcineurin inhibitor immunosuppressant; together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.

If you have been prescribed both Ciprofloxacin and Cyclosporine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Source: FDA structured product labeling (set_id 05b2836d-cd3d-4d7f-970c-66ec2d788667).