Does Ciprofloxacin Interact With Cyclosporine?

However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Severity: Minor

Severity basis: drug interactions section. Combining Ciprofloxacin (Fluoroquinolone antibiotic) and Cyclosporine (Calcineurin inhibitor immunosuppressant) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Source: FDA structured product labeling (set_id 05b2836d-cd3d-4d7f-970c-66ec2d788667).

Ciprofloxacin

Fluoroquinolone antibiotic

Brands: Cipro

View Ciprofloxacin safety profile

Cyclosporine

Calcineurin inhibitor immunosuppressant

Brands: Neoral, Sandimmune, Gengraf

View Cyclosporine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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