Does Codeine Interact With Oxycodone?
If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids (such as oxycodone, hydrocodone, oxymorphone, hydrocodone, or buprenorphine) to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression.
Severity: Moderate
Severity basis: drug interactions section (keywords: monitor, closely). Combining Codeine (Opioid analgesic) and Oxycodone (Opioid analgesic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids (such as oxycodone, hydrocodone, oxymorphone, hydrocodone, or buprenorphine) to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression.
Source: FDA structured product labeling (set_id 010905f9-3bcb-4b50-9fe8-a3ad0010f14c).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Codeine Interactions
- Codeine + Buprenorphine Naloxone(major)
- Codeine + Hydrocodone Acetaminophen(moderate)
- Codeine + Ketoconazole(moderate)
- Codeine + Morphine(moderate)
- Codeine + Alprazolam(minor)
- Codeine + Amiodarone(minor)
- Codeine + Bupropion(minor)
- Codeine + Carbamazepine(minor)
- Codeine + Cyclobenzaprine(minor)
- Codeine + Fluoxetine(minor)
- Codeine + Gabapentin(minor)
- Codeine + Mirtazapine(minor)
- Codeine + Paroxetine(minor)
- Codeine + Phenytoin(minor)
- Codeine + Pregabalin(minor)
- Codeine + Rifampin(minor)
- Codeine + Tramadol(minor)
- Codeine + Trazodone(minor)
Other Oxycodone Interactions
- Oxycodone + Buprenorphine Naloxone(major)
- Oxycodone + Carbamazepine(moderate)
- Oxycodone + Gabapentin(moderate)
- Oxycodone + Itraconazole(moderate)
- Oxycodone + Ketoconazole(moderate)
- Oxycodone + Phenytoin(moderate)
- Oxycodone + Rifampin(moderate)
- Oxycodone + Alprazolam(minor)
- Oxycodone + Cyclobenzaprine(minor)
- Oxycodone + Mirtazapine(minor)
- Oxycodone + Morphine(minor)
- Oxycodone + Pregabalin(minor)
- Oxycodone + Tramadol(minor)
- Oxycodone + Trazodone(minor)