Does Amiodarone Interact With Codeine?

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Amiodarone is a class iii antiarrhythmic and Codeine is a opioid analgesic; together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.

If you have been prescribed both Amiodarone and Codeine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

Risks of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors: The concomitant use of Codeine Sulfate Tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may result in an increase in codeine plasma concentrations and a decrease in active metabolite morphine plasma concentration which could result in an analgesic efficacy reduction or symptoms of opioid withdrawal.

Source: FDA structured product labeling (set_id 010905f9-3bcb-4b50-9fe8-a3ad0010f14c).