Does Oxycodone Interact With Rifampin?

Name: Does Oxycodone Interact With Rifampin?
Creator: OmniRx Health

Examples: Rifampin, carbamazepine, phenytoin Benzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death [see Warnings and Precautions (5.3)] .

Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

Severity: Moderate

Severity basis: drug interactions section (keywords: caution). Combining Oxycodone (Opioid analgesic) and Rifampin (Rifamycin antibiotic (strong CYP3A4 inducer)) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

How This Interaction Works

Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Oxycodone is a opioid analgesic and Rifampin is a rifamycin antibiotic (strong cyp3a4 inducer); together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

If You Take Both Medications

If you have been prescribed both Oxycodone and Rifampin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

From the FDA Label

Examples: Rifampin, carbamazepine, phenytoin Benzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death [see Warnings and Precautions (5.3)] .

Source: FDA structured product labeling (set_id 01db4606-d49c-4b10-a78a-1cf41880a9fb).

Oxycodone

Opioid analgesic

Brands: OxyContin, Roxicodone, Percocet

View Oxycodone safety profile

Rifampin

Rifamycin antibiotic (strong CYP3A4 inducer)

Brands: Rifadin

View Rifampin safety profile

Check these against your full medication list in our free Interaction Checker

Frequently Asked Questions

Can you take Oxycodone and Rifampin together?

Oxycodone and Rifampin have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

How serious is the Oxycodone and Rifampin interaction?

It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: caution). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.

What should I do if I'm taking both Oxycodone and Rifampin?

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

Other Oxycodone Interactions

Other Rifampin Interactions

Sources & References

Learn more about where our data comes from and how we write and review medical content.