Does Codeine Interact With Fluoxetine?

Examples: Paroxetine, fluoxetine, bupropion, quinidine.

Severity: Minor

Severity basis: drug interactions section. Combining Codeine (Opioid analgesic) and Fluoxetine (SSRI antidepressant) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Examples: Paroxetine, fluoxetine, bupropion, quinidine.

Source: FDA structured product labeling (set_id 010905f9-3bcb-4b50-9fe8-a3ad0010f14c).

Codeine

Opioid analgesic

Brands: Tylenol with Codeine

View Codeine safety profile

Fluoxetine

SSRI antidepressant

Brands: Prozac, Sarafem

View Fluoxetine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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