Does Estradiol Interact With Pravastatin?
In a placebo-controlled study of 214 pediatric patients with HeFH, of which 106 were treated with pravastatin (20 mg in the children aged 8-13 years and 40 mg in the adolescents aged 14-18 years) for 2 years, there were no detectable differences seen in any of the endocrine parameters (ACTH, cortisol, DHEAS, FSH, LH, TSH, estradiol [girls] or testosterone [boys]) relative to placebo.
Severity: Minor
Severity basis: warnings section. Combining Estradiol (Estrogen) and Pravastatin (HMG-CoA reductase inhibitor (statin)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
In a placebo-controlled study of 214 pediatric patients with HeFH, of which 106 were treated with pravastatin (20 mg in the children aged 8-13 years and 40 mg in the adolescents aged 14-18 years) for 2 years, there were no detectable differences seen in any of the endocrine parameters (ACTH, cortisol, DHEAS, FSH, LH, TSH, estradiol [girls] or testosterone [boys]) relative to placebo.
Source: FDA structured product labeling (set_id 01beb7e2-ba01-4f2f-8554-4a8ec0941c9f).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Estradiol Interactions
Other Pravastatin Interactions
- Pravastatin + Clarithromycin(major)
- Pravastatin + Gemfibrozil(major)
- Pravastatin + Colchicine(moderate)
- Pravastatin + Cyclosporine(moderate)
- Pravastatin + Ketoconazole(moderate)
- Pravastatin + Spironolactone(moderate)
- Pravastatin + Azithromycin(minor)
- Pravastatin + Diltiazem(minor)
- Pravastatin + Testosterone(minor)