Does Clarithromycin Interact With Simvastatin?
4.5 Lomitapide, Lovastatin, and Simvastatin Concomitant administration of clarithromycin tablets with lomitapide is contraindicated due to potential for markedly increased transaminases [see Warnings and Precautions ( 5.4 ) and Drug Interactions ( 7 )].
Severity: Contraindicated
Severity basis: contraindications section (keywords: contraindicated). Combining Clarithromycin (Macrolide antibiotic) and Simvastatin (HMG-CoA reductase inhibitor (statin)) is classified as a contraindicated interaction.
What to Do
This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.
From the FDA Label
4.5 Lomitapide, Lovastatin, and Simvastatin Concomitant administration of clarithromycin tablets with lomitapide is contraindicated due to potential for markedly increased transaminases [see Warnings and Precautions ( 5.4 ) and Drug Interactions ( 7 )].
Source: FDA structured product labeling (set_id 0be243c6-de02-45dd-8210-cab1bbc8dfa7).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Clarithromycin Interactions
- Clarithromycin + Colchicine(contraindicated)
- Clarithromycin + Lansoprazole(contraindicated)
- Clarithromycin + Lovastatin(contraindicated)
- Clarithromycin + Amiodarone(major)
- Clarithromycin + Atorvastatin(major)
- Clarithromycin + Cyclosporine(major)
- Clarithromycin + Fluconazole(major)
- Clarithromycin + Fluticasone Salmeterol(major)
- Clarithromycin + Pioglitazone(major)
- Clarithromycin + Pravastatin(major)
- Clarithromycin + Quetiapine(major)
- Clarithromycin + Ticagrelor(major)
- Clarithromycin + Trazodone(major)
- Clarithromycin + Alprazolam(moderate)
- Clarithromycin + Amlodipine(moderate)
- Clarithromycin + Aripiprazole(moderate)
- Clarithromycin + Carbamazepine(moderate)
- Clarithromycin + Dabigatran(moderate)
- Clarithromycin + Digoxin(moderate)
- Clarithromycin + Diltiazem(moderate)
- Clarithromycin + Glimepiride(moderate)
- Clarithromycin + Itraconazole(moderate)
- Clarithromycin + Nifedipine(moderate)
- Clarithromycin + Phenytoin(moderate)
- Clarithromycin + Rifampin(moderate)
- Clarithromycin + Rivaroxaban(moderate)
- Clarithromycin + Sildenafil(moderate)
- Clarithromycin + Tacrolimus(moderate)
- Clarithromycin + Tadalafil(moderate)
- Clarithromycin + Valproic Acid(moderate)
- Clarithromycin + Verapamil(moderate)
- Clarithromycin + Warfarin(moderate)
- Clarithromycin + Apixaban(minor)
- Clarithromycin + Eszopiclone(minor)
- Clarithromycin + Lorazepam(minor)
- Clarithromycin + Methylprednisolone(minor)
- Clarithromycin + Omeprazole(minor)
- Clarithromycin + Oxybutynin(minor)
- Clarithromycin + Temazepam(minor)
Other Simvastatin Interactions
- Simvastatin + Cyclosporine(contraindicated)
- Simvastatin + Gemfibrozil(contraindicated)
- Simvastatin + Itraconazole(contraindicated)
- Simvastatin + Colchicine(moderate)
- Simvastatin + Digoxin(moderate)
- Simvastatin + Phenytoin(moderate)
- Simvastatin + Ticagrelor(moderate)
- Simvastatin + Amiodarone(minor)
- Simvastatin + Amlodipine(minor)
- Simvastatin + Dapagliflozin(minor)
- Simvastatin + Diltiazem(minor)
- Simvastatin + Ezetimibe(minor)
- Simvastatin + Fluconazole(minor)
- Simvastatin + Ketoconazole(minor)
- Simvastatin + Ramipril(minor)
- Simvastatin + Rifampin(minor)
- Simvastatin + Verapamil(minor)
- Simvastatin + Warfarin(minor)