Does Digoxin Interact With Simvastatin?
( 7.2 ) Digoxin: During simvastatin initiation, monitor digoxin levels.
Severity: Moderate
Severity basis: drug interactions section (keywords: monitor). Combining Digoxin (Cardiac glycoside) and Simvastatin (HMG-CoA reductase inhibitor (statin)) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
( 7.2 ) Digoxin: During simvastatin initiation, monitor digoxin levels.
Source: FDA structured product labeling (set_id 00896fff-081d-4553-be8c-1999a8a73dda).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Digoxin Interactions
- Digoxin + Albuterol(moderate)
- Digoxin + Atorvastatin(moderate)
- Digoxin + Carvedilol(moderate)
- Digoxin + Clarithromycin(moderate)
- Digoxin + Itraconazole(moderate)
- Digoxin + Lansoprazole(moderate)
- Digoxin + Pantoprazole(moderate)
- Digoxin + Phenytoin(moderate)
- Digoxin + Tamsulosin(moderate)
- Digoxin + Ticagrelor(moderate)
- Digoxin + Trazodone(moderate)
- Digoxin + Verapamil(moderate)
- Digoxin + Alprazolam(minor)
- Digoxin + Amiodarone(minor)
- Digoxin + Azithromycin(minor)
- Digoxin + Canagliflozin(minor)
- Digoxin + Celecoxib(minor)
- Digoxin + Colchicine(minor)
- Digoxin + Cyclosporine(minor)
- Digoxin + Dapagliflozin(minor)
- Digoxin + Diclofenac(minor)
- Digoxin + Dicyclomine(minor)
- Digoxin + Diltiazem(minor)
- Digoxin + Enalapril(minor)
- Digoxin + Esomeprazole(minor)
- Digoxin + Finasteride(minor)
- Digoxin + Hydroxychloroquine(minor)
- Digoxin + Ibuprofen(minor)
- Digoxin + Indomethacin(minor)
- Digoxin + Ketoconazole(minor)
- Digoxin + Levofloxacin(minor)
- Digoxin + Lovastatin(minor)
- Digoxin + Metformin(minor)
- Digoxin + Metoclopramide(minor)
- Digoxin + Montelukast(minor)
- Digoxin + Naproxen(minor)
- Digoxin + Nifedipine(minor)
- Digoxin + Omeprazole(minor)
- Digoxin + Raloxifene(minor)
- Digoxin + Ramipril(minor)
- Digoxin + Rifampin(minor)
- Digoxin + Risperidone(minor)
- Digoxin + Sertraline(minor)
- Digoxin + Spironolactone(minor)
- Digoxin + Sucralfate(minor)
- Digoxin + Sulfasalazine(minor)
- Digoxin + Tadalafil(minor)
- Digoxin + Telmisartan(minor)
- Digoxin + Tramadol(minor)
Other Simvastatin Interactions
- Simvastatin + Clarithromycin(contraindicated)
- Simvastatin + Cyclosporine(contraindicated)
- Simvastatin + Gemfibrozil(contraindicated)
- Simvastatin + Itraconazole(contraindicated)
- Simvastatin + Colchicine(moderate)
- Simvastatin + Phenytoin(moderate)
- Simvastatin + Ticagrelor(moderate)
- Simvastatin + Amiodarone(minor)
- Simvastatin + Amlodipine(minor)
- Simvastatin + Dapagliflozin(minor)
- Simvastatin + Diltiazem(minor)
- Simvastatin + Ezetimibe(minor)
- Simvastatin + Fluconazole(minor)
- Simvastatin + Ketoconazole(minor)
- Simvastatin + Ramipril(minor)
- Simvastatin + Rifampin(minor)
- Simvastatin + Verapamil(minor)
- Simvastatin + Warfarin(minor)