Does Cyclosporine Interact With Simvastatin?

Concomitant use of cyclosporine, danazol or gemfibrozil [see DRUG INTERACTIONS ( 7.1 )].

Severity: Contraindicated

Severity basis: contraindications section (keywords: contraindications section). Combining Cyclosporine (Calcineurin inhibitor immunosuppressant) and Simvastatin (HMG-CoA reductase inhibitor (statin)) is classified as a contraindicated interaction.

What to Do

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

From the FDA Label

Concomitant use of cyclosporine, danazol or gemfibrozil [see DRUG INTERACTIONS ( 7.1 )].

Source: FDA structured product labeling (set_id 00896fff-081d-4553-be8c-1999a8a73dda).

Cyclosporine

Calcineurin inhibitor immunosuppressant

Brands: Neoral, Sandimmune, Gengraf

View Cyclosporine safety profile

Simvastatin

HMG-CoA reductase inhibitor (statin)

Brands: Zocor

View Simvastatin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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