Does Gemfibrozil Interact With Pravastatin?

7.4 Gemfibrozil Due to an increased risk of myopathy/rhabdomyolysis when HMG-CoA reductase inhibitors are coadministered with gemfibrozil, concomitant administration of Pravastatin Sodium with gemfibrozil should be avoided [see Warnings and Precautions (5.1) ].

Severity: Major

Severity basis: drug interactions section (keywords: avoid). Combining Gemfibrozil (Fibrate) and Pravastatin (HMG-CoA reductase inhibitor (statin)) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

7.4 Gemfibrozil Due to an increased risk of myopathy/rhabdomyolysis when HMG-CoA reductase inhibitors are coadministered with gemfibrozil, concomitant administration of Pravastatin Sodium with gemfibrozil should be avoided [see Warnings and Precautions (5.1) ].

Source: FDA structured product labeling (set_id 01beb7e2-ba01-4f2f-8554-4a8ec0941c9f).

Gemfibrozil

Fibrate

Brands: Lopid

View Gemfibrozil safety profile

Pravastatin

HMG-CoA reductase inhibitor (statin)

Brands: Pravachol

View Pravastatin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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