Does Folic Acid Interact With Valproic Acid?

Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population [see Use in Specific Populations ( 8.1 )] .

Severity: Minor

Severity basis: warnings section. Combining Folic Acid (B-vitamin supplement) and Valproic Acid (Anticonvulsant / mood stabilizer) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population [see Use in Specific Populations ( 8.1 )] .

Source: FDA structured product labeling (set_id 1286ab49-fa34-488e-e063-6394a90ad582).

Folic Acid

B-vitamin supplement

Brands: FA-8

View Folic Acid safety profile

Valproic Acid

Anticonvulsant / mood stabilizer

Brands: Depakote, Depakene

View Valproic Acid safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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