Does Aspirin Interact With Valproic Acid?
Therefore increased monitoring of valproate and concomitant drug concentrations and dosage adjustment are indicated whenever enzyme- inducing or inhibiting drugs are introduced or withdrawn ( 7.1 ) Aspirin, carbapenem antibiotics, estrogen-containing hormonal contraceptives: Monitoring of valproate concentrations is recommended ( 7.1 ) Co-administration of valproate can affect the pharmacokinetics of other drugs (e.g.
Severity: Moderate
Severity basis: drug interactions section (keywords: monitor, dosage adjustment). Combining Aspirin (Antiplatelet / NSAID) and Valproic Acid (Anticonvulsant / mood stabilizer) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Aspirin is a antiplatelet / nsaid and Valproic Acid is a anticonvulsant / mood stabilizer; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Aspirin and Valproic Acid, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Therefore increased monitoring of valproate and concomitant drug concentrations and dosage adjustment are indicated whenever enzyme- inducing or inhibiting drugs are introduced or withdrawn ( 7.1 ) Aspirin, carbapenem antibiotics, estrogen-containing hormonal contraceptives: Monitoring of valproate concentrations is recommended ( 7.1 ) Co-administration of valproate can affect the pharmacokinetics of other drugs (e.g.
Source: FDA structured product labeling (set_id 1286ab49-fa34-488e-e063-6394a90ad582).
Valproic Acid
Anticonvulsant / mood stabilizer
Brands: Depakote, Depakene
View Valproic Acid safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Aspirin and Valproic Acid together?
Aspirin and Valproic Acid have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Aspirin and Valproic Acid interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: monitor, dosage adjustment). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Aspirin and Valproic Acid?
If you have been prescribed both Aspirin and Valproic Acid, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Aspirin Interactions
- Aspirin + Celecoxib(contraindicated)
- Aspirin + Indomethacin(contraindicated)
- Aspirin + Ketorolac(contraindicated)
- Aspirin + Meloxicam(contraindicated)
- Aspirin + Naproxen(contraindicated)
- Aspirin + Fluoxetine(major)
- Aspirin + Ibuprofen(major)
- Aspirin + Methotrexate(major)
- Aspirin + Montelukast(major)
- Aspirin + Alendronate(moderate)
- Aspirin + Citalopram(moderate)
- Aspirin + Desvenlafaxine(moderate)
- Aspirin + Edoxaban(moderate)
- Aspirin + Escitalopram(moderate)
- Aspirin + Methylprednisolone(moderate)
- Aspirin + Paroxetine(moderate)
- Aspirin + Rivaroxaban(moderate)
- Aspirin + Spironolactone(moderate)
- Aspirin + Trazodone(moderate)
- Aspirin + Apixaban(minor)
- Aspirin + Atenolol(minor)
- Aspirin + Atomoxetine(minor)
- Aspirin + Dexamethasone(minor)
- Aspirin + Diclofenac(minor)
- Aspirin + Duloxetine(minor)
- Aspirin + Enoxaparin(minor)
- Aspirin + Finasteride(minor)
- Aspirin + Furosemide(minor)
- Aspirin + Levothyroxine(minor)
- Aspirin + Nitroglycerin(minor)
- Aspirin + Oseltamivir(minor)
- Aspirin + Sertraline(minor)
- Aspirin + Sildenafil(minor)
- Aspirin + Tadalafil(minor)
- Aspirin + Venlafaxine(minor)
- Aspirin + Verapamil(minor)
- Aspirin + Warfarin(minor)
Other Valproic Acid Interactions
- Valproic Acid + Olanzapine(contraindicated)
- Valproic Acid + Topiramate(major)
- Valproic Acid + Amitriptyline(moderate)
- Valproic Acid + Aripiprazole(moderate)
- Valproic Acid + Carbamazepine(moderate)
- Valproic Acid + Clarithromycin(moderate)
- Valproic Acid + Diazepam(moderate)
- Valproic Acid + Lamotrigine(moderate)
- Valproic Acid + Nortriptyline(moderate)
- Valproic Acid + Warfarin(moderate)
- Valproic Acid + Acetaminophen(minor)
- Valproic Acid + Clonazepam(minor)
- Valproic Acid + Folic Acid(minor)
- Valproic Acid + Gabapentin(minor)
- Valproic Acid + Lithium(minor)
- Valproic Acid + Lorazepam(minor)
- Valproic Acid + Phenytoin(minor)
- Valproic Acid + Pregabalin(minor)
- Valproic Acid + Quetiapine(minor)
- Valproic Acid + Rifampin(minor)
- Valproic Acid + Risperidone(minor)
- Valproic Acid + Sertraline(minor)