Does Lithium Interact With Valproic Acid?

Lithium Co-administration of valproate (500 mg BID) and lithium carbonate (300 mg TID) to normal male volunteers (n = 16) had no effect on the steady-state kinetics of lithium.

Severity: Minor

Severity basis: drug interactions section. Combining Lithium (Mood stabilizer) and Valproic Acid (Anticonvulsant / mood stabilizer) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Lithium Co-administration of valproate (500 mg BID) and lithium carbonate (300 mg TID) to normal male volunteers (n = 16) had no effect on the steady-state kinetics of lithium.

Source: FDA structured product labeling (set_id 1286ab49-fa34-488e-e063-6394a90ad582).

Lithium

Mood stabilizer

Brands: Lithobid, Eskalith

View Lithium safety profile

Valproic Acid

Anticonvulsant / mood stabilizer

Brands: Depakote, Depakene

View Valproic Acid safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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