Does Olanzapine Interact With Valproic Acid?

For specific information about the contraindications of lithium or valproate, refer to the Contraindications section of the package inserts for these other products.

Severity: Contraindicated

Severity basis: contraindications section (keywords: contraindications section). Combining Olanzapine (Atypical antipsychotic) and Valproic Acid (Anticonvulsant / mood stabilizer) is classified as a contraindicated interaction.

What to Do

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

From the FDA Label

For specific information about the contraindications of lithium or valproate, refer to the Contraindications section of the package inserts for these other products.

Source: FDA structured product labeling (set_id 002dd00f-7946-ea4f-e063-6294a90a5916).

Olanzapine

Atypical antipsychotic

Brands: Zyprexa

View Olanzapine safety profile

Valproic Acid

Anticonvulsant / mood stabilizer

Brands: Depakote, Depakene

View Valproic Acid safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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