Does Metoprolol Interact With Venlafaxine?
Metoprolol Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of metoprolol by approximately 30 to 40% without altering the plasma concentrations of its active metabolite, α-hydroxymetoprolol.
Severity: Minor
Severity basis: drug interactions section. Combining Metoprolol (Beta-blocker) and Venlafaxine (SNRI antidepressant) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Metoprolol Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of metoprolol by approximately 30 to 40% without altering the plasma concentrations of its active metabolite, α-hydroxymetoprolol.
Source: FDA structured product labeling (set_id 017a84aa-0e1f-f560-e063-6294a90a9069).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Metoprolol Interactions
Other Venlafaxine Interactions
- Venlafaxine + Aripiprazole(moderate)
- Venlafaxine + Itraconazole(moderate)
- Venlafaxine + Alprazolam(minor)
- Venlafaxine + Aspirin(minor)
- Venlafaxine + Bupropion(minor)
- Venlafaxine + Buspirone(minor)
- Venlafaxine + Desvenlafaxine(minor)
- Venlafaxine + Diazepam(minor)
- Venlafaxine + Fluoxetine(minor)
- Venlafaxine + Ketoconazole(minor)
- Venlafaxine + Lithium(minor)
- Venlafaxine + Paroxetine(minor)
- Venlafaxine + Risperidone(minor)
- Venlafaxine + Tramadol(minor)
- Venlafaxine + Warfarin(minor)