Does Lithium Interact With Venlafaxine?

Lithium The steady-state pharmacokinetics of venlafaxine administered at 150 mg/day were not affected when a single 600 mg oral dose of lithium was administered to 12 healthy male subjects.

Severity: Minor

Severity basis: drug interactions section. Combining Lithium (Mood stabilizer) and Venlafaxine (SNRI antidepressant) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Lithium The steady-state pharmacokinetics of venlafaxine administered at 150 mg/day were not affected when a single 600 mg oral dose of lithium was administered to 12 healthy male subjects.

Source: FDA structured product labeling (set_id 017a84aa-0e1f-f560-e063-6294a90a9069).

Lithium

Mood stabilizer

Brands: Lithobid, Eskalith

View Lithium safety profile

Venlafaxine

SNRI antidepressant

Brands: Effexor

View Venlafaxine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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