Does Fluoxetine Interact With Metoprolol?

7.3 CYP2D6 Inhibitors Drugs that are strong inhibitors of CYP2D6 such as quinidine, fluoxetine, paroxetine, and propafenone were shown to double metoprolol concentrations.

Severity: Minor

Severity basis: drug interactions section. Combining Fluoxetine (SSRI antidepressant) and Metoprolol (Beta-blocker) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

7.3 CYP2D6 Inhibitors Drugs that are strong inhibitors of CYP2D6 such as quinidine, fluoxetine, paroxetine, and propafenone were shown to double metoprolol concentrations.

Source: FDA structured product labeling (set_id 00de1f16-f979-4dbf-aa60-246ffac8d410).

Fluoxetine

SSRI antidepressant

Brands: Prozac, Sarafem

View Fluoxetine safety profile

Metoprolol

Beta-blocker

Brands: Lopressor, Toprol XL

View Metoprolol safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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