Does Risperidone Interact With Venlafaxine?

Risperidone Venlafaxine administered under steady-state conditions at 150 mg/day slightly inhibited the CYP2D6-mediated metabolism of risperidone (administered as a single 1 mg oral dose) to its active metabolite, 9-hydroxyrisperidone, resulting in an approximate 32% increase in risperidone AUC.

Severity: Minor

Severity basis: drug interactions section. Combining Risperidone (Atypical antipsychotic) and Venlafaxine (SNRI antidepressant) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Risperidone Venlafaxine administered under steady-state conditions at 150 mg/day slightly inhibited the CYP2D6-mediated metabolism of risperidone (administered as a single 1 mg oral dose) to its active metabolite, 9-hydroxyrisperidone, resulting in an approximate 32% increase in risperidone AUC.

Source: FDA structured product labeling (set_id 017a84aa-0e1f-f560-e063-6294a90a9069).

Risperidone

Atypical antipsychotic

Brands: Risperdal

View Risperidone safety profile

Venlafaxine

SNRI antidepressant

Brands: Effexor

View Venlafaxine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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