Does Pravastatin Interact With Testosterone?
In a study of 21 males, the mean testosterone response to human chorionic gonadotropin was significantly reduced (p<0.004) after 16 weeks of treatment with 40 mg of pravastatin.
Severity: Minor
Severity basis: warnings section. Combining Pravastatin (HMG-CoA reductase inhibitor (statin)) and Testosterone (Androgen (testosterone replacement)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
In a study of 21 males, the mean testosterone response to human chorionic gonadotropin was significantly reduced (p<0.004) after 16 weeks of treatment with 40 mg of pravastatin.
Source: FDA structured product labeling (set_id 01beb7e2-ba01-4f2f-8554-4a8ec0941c9f).
Testosterone
Androgen (testosterone replacement)
Brands: Depo-Testosterone, Xyosted
View Testosterone safety profileCheck these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Pravastatin Interactions
- Pravastatin + Clarithromycin(major)
- Pravastatin + Gemfibrozil(major)
- Pravastatin + Colchicine(moderate)
- Pravastatin + Cyclosporine(moderate)
- Pravastatin + Ketoconazole(moderate)
- Pravastatin + Spironolactone(moderate)
- Pravastatin + Azithromycin(minor)
- Pravastatin + Diltiazem(minor)
- Pravastatin + Estradiol(minor)