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    HomeMedication GuideDrug InteractionsCyclosporine + Pravastatin
    Moderate interaction

    Does Cyclosporine Interact With Pravastatin?

    7 DRUG INTERACTIONS For the concurrent therapy of either cyclosporine, fibrates, niacin (nicotinic acid), or erythromycin, the risk of myopathy increases [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].

    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    Severity: Moderate

    Severity basis: drug interactions section (keywords: caution). Combining Cyclosporine (Calcineurin inhibitor immunosuppressant) and Pravastatin (HMG-CoA reductase inhibitor (statin)) is classified as a moderate interaction.

    What to Do

    Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How This Interaction Works

    Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Cyclosporine is a calcineurin inhibitor immunosuppressant and Pravastatin is a hmg-coa reductase inhibitor (statin); together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

    If You Take Both Medications

    If you have been prescribed both Cyclosporine and Pravastatin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    From the FDA Label

    7 DRUG INTERACTIONS For the concurrent therapy of either cyclosporine, fibrates, niacin (nicotinic acid), or erythromycin, the risk of myopathy increases [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].

    Source: FDA structured product labeling (set_id 01beb7e2-ba01-4f2f-8554-4a8ec0941c9f).

    Cyclosporine

    Calcineurin inhibitor immunosuppressant

    Brands: Neoral, Sandimmune, Gengraf

    View Cyclosporine safety profile

    Pravastatin

    HMG-CoA reductase inhibitor (statin)

    Brands: Pravachol

    View Pravastatin safety profile

    Check these against your full medication list in our free Interaction Checker

    Frequently Asked Questions

    Can you take Cyclosporine and Pravastatin together?

    Cyclosporine and Pravastatin have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How serious is the Cyclosporine and Pravastatin interaction?

    It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: caution). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.

    What should I do if I'm taking both Cyclosporine and Pravastatin?

    If you have been prescribed both Cyclosporine and Pravastatin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Questions About Your Medications?

    A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

    Other Cyclosporine Interactions

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.