Does Carvedilol Interact With Paroxetine?
( 7.8 ) 7.1 CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology ( 12.3 )] .
Severity: Minor
Severity basis: drug interactions section. Combining Carvedilol (Beta-blocker) and Paroxetine (SSRI antidepressant) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
( 7.8 ) 7.1 CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology ( 12.3 )] .
Source: FDA structured product labeling (set_id 010290af-81f4-0037-e063-6394a90a4638).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Carvedilol Interactions
Other Paroxetine Interactions
- Paroxetine + Aripiprazole(moderate)
- Paroxetine + Aspirin(moderate)
- Paroxetine + Atomoxetine(moderate)
- Paroxetine + Phenytoin(moderate)
- Paroxetine + Tamsulosin(moderate)
- Paroxetine + Warfarin(moderate)
- Paroxetine + Amitriptyline(minor)
- Paroxetine + Bupropion(minor)
- Paroxetine + Buspirone(minor)
- Paroxetine + Clopidogrel(minor)
- Paroxetine + Codeine(minor)
- Paroxetine + Duloxetine(minor)
- Paroxetine + Lithium(minor)
- Paroxetine + Metoprolol(minor)
- Paroxetine + Risperidone(minor)
- Paroxetine + Sertraline(minor)
- Paroxetine + Tramadol(minor)
- Paroxetine + Venlafaxine(minor)