Does Paroxetine Interact With Tramadol?
Examples Quinidine, fluoxetine, paroxetine and bupropion Inhibitors of CYP3A4 Clinical Impact: The concomitant use of tramadol hydrochloride extended-release tablets and CYP3A4 inhibitors can increase the plasma concentration of tramadol and may result in a greater amount of metabolism via CYP2D6 and greater levels of M1.
Severity: Minor
Severity basis: drug interactions section. Combining Paroxetine (SSRI antidepressant) and Tramadol (Opioid analgesic) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Examples Quinidine, fluoxetine, paroxetine and bupropion Inhibitors of CYP3A4 Clinical Impact: The concomitant use of tramadol hydrochloride extended-release tablets and CYP3A4 inhibitors can increase the plasma concentration of tramadol and may result in a greater amount of metabolism via CYP2D6 and greater levels of M1.
Source: FDA structured product labeling (set_id 004de5a4-80f8-4040-a6ea-be5e99352a36).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Paroxetine Interactions
- Paroxetine + Aripiprazole(moderate)
- Paroxetine + Aspirin(moderate)
- Paroxetine + Atomoxetine(moderate)
- Paroxetine + Phenytoin(moderate)
- Paroxetine + Tamsulosin(moderate)
- Paroxetine + Warfarin(moderate)
- Paroxetine + Amitriptyline(minor)
- Paroxetine + Bupropion(minor)
- Paroxetine + Buspirone(minor)
- Paroxetine + Carvedilol(minor)
- Paroxetine + Clopidogrel(minor)
- Paroxetine + Codeine(minor)
- Paroxetine + Duloxetine(minor)
- Paroxetine + Lithium(minor)
- Paroxetine + Metoprolol(minor)
- Paroxetine + Risperidone(minor)
- Paroxetine + Sertraline(minor)
- Paroxetine + Venlafaxine(minor)
Other Tramadol Interactions
- Tramadol + Buprenorphine Naloxone(major)
- Tramadol + Carbamazepine(moderate)
- Tramadol + Fluoxetine(moderate)
- Tramadol + Ketoconazole(moderate)
- Tramadol + Ondansetron(moderate)
- Tramadol + Phenytoin(moderate)
- Tramadol + Rifampin(moderate)
- Tramadol + Alprazolam(minor)
- Tramadol + Amiodarone(minor)
- Tramadol + Amphetamine Dextroamphetamine(minor)
- Tramadol + Bupropion(minor)
- Tramadol + Citalopram(minor)
- Tramadol + Codeine(minor)
- Tramadol + Cyclobenzaprine(minor)
- Tramadol + Desvenlafaxine(minor)
- Tramadol + Digoxin(minor)
- Tramadol + Duloxetine(minor)
- Tramadol + Escitalopram(minor)
- Tramadol + Gabapentin(minor)
- Tramadol + Lisdexamfetamine(minor)
- Tramadol + Lithium(minor)
- Tramadol + Mirtazapine(minor)
- Tramadol + Morphine(minor)
- Tramadol + Naltrexone(minor)
- Tramadol + Nortriptyline(minor)
- Tramadol + Oxycodone(minor)
- Tramadol + Pregabalin(minor)
- Tramadol + Sertraline(minor)
- Tramadol + Trazodone(minor)
- Tramadol + Venlafaxine(minor)
- Tramadol + Warfarin(minor)