Does Carvedilol Interact With Fluconazole?

The concomitant administration of amiodarone or other CYP2C9 inhibitors such as fluconazole with carvedilol may enhance the β-blocking activity, resulting in further slowing of the heart rate or cardiac conduction.

Severity: Minor

Severity basis: drug interactions section. Combining Carvedilol (Beta-blocker) and Fluconazole (Azole antifungal) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

The concomitant administration of amiodarone or other CYP2C9 inhibitors such as fluconazole with carvedilol may enhance the β-blocking activity, resulting in further slowing of the heart rate or cardiac conduction.

Source: FDA structured product labeling (set_id 010290af-81f4-0037-e063-6394a90a4638).

Carvedilol

Beta-blocker

Brands: Coreg

View Carvedilol safety profile

Fluconazole

Azole antifungal

Brands: Diflucan

View Fluconazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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