Does Aspirin Interact With Paroxetine?

( 5.4 , 8.1 ) Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, other antiplatelet drugs, warfarin, and other anticoagulant drugs may increase risk.

Severity: Moderate

Severity basis: warnings section (keywords: increased risk, may increase). Combining Aspirin (Antiplatelet / NSAID) and Paroxetine (SSRI antidepressant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

( 5.4 , 8.1 ) Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, other antiplatelet drugs, warfarin, and other anticoagulant drugs may increase risk.

Source: FDA structured product labeling (set_id 05ec70fd-4c65-495f-ba12-e8433a10b655).

Aspirin

Antiplatelet / NSAID

Brands: Bayer, Ecotrin, Bufferin

View Aspirin safety profile

Paroxetine

SSRI antidepressant

Brands: Paxil, Brisdelle

View Paroxetine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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