Does Clopidogrel Interact With Omeprazole?
Omeprazole or Esomeprazole Avoid concomitant use of clopidogrel with omeprazole or esomeprazole.
Severity: Major
Severity basis: drug interactions section (keywords: avoid). Combining Clopidogrel (P2Y12 antiplatelet) and Omeprazole (Proton pump inhibitor) is classified as a major interaction.
What to Do
The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Clopidogrel is a p2y12 antiplatelet and Omeprazole is a proton pump inhibitor; together they are documented as a major interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Clopidogrel and Omeprazole, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Omeprazole or Esomeprazole Avoid concomitant use of clopidogrel with omeprazole or esomeprazole.
Source: FDA structured product labeling (set_id 0078fb3d-3595-4ae1-a059-1d5e81c879cf).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Clopidogrel and Omeprazole together?
Clopidogrel and Omeprazole have a documented major interaction. The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How serious is the Clopidogrel and Omeprazole interaction?
It is classified as a major interaction, based on the FDA label's drug interactions section (keywords: avoid). A major interaction can cause serious harm and often calls for a change in therapy or close monitoring.
What should I do if I'm taking both Clopidogrel and Omeprazole?
If you have been prescribed both Clopidogrel and Omeprazole, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Clopidogrel Interactions
- Clopidogrel + Esomeprazole(major)
- Clopidogrel + Rifampin(major)
- Clopidogrel + Lansoprazole(moderate)
- Clopidogrel + Morphine(moderate)
- Clopidogrel + Pantoprazole(moderate)
- Clopidogrel + Rivaroxaban(moderate)
- Clopidogrel + Apixaban(minor)
- Clopidogrel + Bupropion(minor)
- Clopidogrel + Paroxetine(minor)
- Clopidogrel + Trazodone(minor)
- Clopidogrel + Warfarin(minor)
Other Omeprazole Interactions
- Omeprazole + Aripiprazole(moderate)
- Omeprazole + Phenytoin(moderate)
- Omeprazole + Tacrolimus(moderate)
- Omeprazole + Atomoxetine(minor)
- Omeprazole + Carbamazepine(minor)
- Omeprazole + Clarithromycin(minor)
- Omeprazole + Diazepam(minor)
- Omeprazole + Digoxin(minor)
- Omeprazole + Modafinil(minor)
- Omeprazole + Olanzapine(minor)
- Omeprazole + Warfarin(minor)