Does Clopidogrel Interact With Omeprazole?

Omeprazole or Esomeprazole Avoid concomitant use of clopidogrel with omeprazole or esomeprazole.

Severity: Major

Severity basis: drug interactions section (keywords: avoid). Combining Clopidogrel (P2Y12 antiplatelet) and Omeprazole (Proton pump inhibitor) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

Omeprazole or Esomeprazole Avoid concomitant use of clopidogrel with omeprazole or esomeprazole.

Source: FDA structured product labeling (set_id 0078fb3d-3595-4ae1-a059-1d5e81c879cf).

Clopidogrel

P2Y12 antiplatelet

Brands: Plavix

View Clopidogrel safety profile

Omeprazole

Proton pump inhibitor

Brands: Prilosec

View Omeprazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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