Does Clopidogrel Interact With Pantoprazole?
Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of clopidogrel than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].
Severity: Moderate
Severity basis: drug interactions section (keywords: caution). Combining Clopidogrel (P2Y12 antiplatelet) and Pantoprazole (Proton pump inhibitor) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of clopidogrel than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].
Source: FDA structured product labeling (set_id 0078fb3d-3595-4ae1-a059-1d5e81c879cf).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Clopidogrel Interactions
- Clopidogrel + Esomeprazole(major)
- Clopidogrel + Omeprazole(major)
- Clopidogrel + Rifampin(major)
- Clopidogrel + Lansoprazole(moderate)
- Clopidogrel + Morphine(moderate)
- Clopidogrel + Rivaroxaban(moderate)
- Clopidogrel + Apixaban(minor)
- Clopidogrel + Bupropion(minor)
- Clopidogrel + Paroxetine(minor)
- Clopidogrel + Trazodone(minor)
- Clopidogrel + Warfarin(minor)