Does Clopidogrel Interact With Rivaroxaban?

7.4 Anticoagulants and NSAIDs/Aspirin Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding [see Clinical Pharmacology (12.3) ].

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Clopidogrel (P2Y12 antiplatelet) and Rivaroxaban (Factor Xa inhibitor anticoagulant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

7.4 Anticoagulants and NSAIDs/Aspirin Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding [see Clinical Pharmacology (12.3) ].

Source: FDA structured product labeling (set_id 10db92f9-2300-4a80-836b-673e1ae91610).

Clopidogrel

P2Y12 antiplatelet

Brands: Plavix

View Clopidogrel safety profile

Rivaroxaban

Factor Xa inhibitor anticoagulant

Brands: Xarelto

View Rivaroxaban safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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