Does Apixaban Interact With Clopidogrel?

APPRAISE-2, a placebo-controlled clinical trial of apixaban in high-risk, post-acute coronary syndrome patients treated with aspirin or the combination of aspirin and clopidogrel, was terminated early due to a higher rate of bleeding with apixaban compared to placebo.

Severity: Minor

Severity basis: drug interactions section. Combining Apixaban (Factor Xa inhibitor anticoagulant) and Clopidogrel (P2Y12 antiplatelet) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

APPRAISE-2, a placebo-controlled clinical trial of apixaban in high-risk, post-acute coronary syndrome patients treated with aspirin or the combination of aspirin and clopidogrel, was terminated early due to a higher rate of bleeding with apixaban compared to placebo.

Source: FDA structured product labeling (set_id 095a08ac-cf0e-497e-a682-ddef38d6b29c).

Apixaban

Factor Xa inhibitor anticoagulant

Brands: Eliquis

View Apixaban safety profile

Clopidogrel

P2Y12 antiplatelet

Brands: Plavix

View Clopidogrel safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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