Does Clopidogrel Interact With Lansoprazole?

Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of clopidogrel than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].

Severity: Moderate

Severity basis: drug interactions section (keywords: caution). Combining Clopidogrel (P2Y12 antiplatelet) and Lansoprazole (Proton pump inhibitor) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of clopidogrel than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].

Source: FDA structured product labeling (set_id 0078fb3d-3595-4ae1-a059-1d5e81c879cf).

Clopidogrel

P2Y12 antiplatelet

Brands: Plavix

View Clopidogrel safety profile

Lansoprazole

Proton pump inhibitor

Brands: Prevacid

View Lansoprazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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