Does Glimepiride Interact With Olanzapine?
The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., …
Severity: Moderate
Severity basis: drug interactions section (keywords: may reduce). Combining Glimepiride (Sulfonylurea) and Olanzapine (Atypical antipsychotic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., …
Source: FDA structured product labeling (set_id 0003458f-352a-46fa-9d99-230daa76ae29).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Glimepiride Interactions
Other Olanzapine Interactions
- Olanzapine + Fluoxetine(contraindicated)
- Olanzapine + Lithium(contraindicated)
- Olanzapine + Valproic Acid(contraindicated)
- Olanzapine + Carbamazepine(moderate)
- Olanzapine + Diazepam(moderate)
- Olanzapine + Insulin Aspart(moderate)
- Olanzapine + Insulin Glargine(moderate)
- Olanzapine + Carbidopa Levodopa(minor)
- Olanzapine + Eszopiclone(minor)
- Olanzapine + Omeprazole(minor)
- Olanzapine + Quetiapine(minor)
- Olanzapine + Rifampin(minor)
- Olanzapine + Warfarin(minor)