Does Insulin Aspart Interact With Olanzapine?
Drugs That May Decrease the Blood Glucose Lowering Effect of NOVOLOG Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Severity: Moderate
Severity basis: drug interactions section (keywords: may decrease). Combining Insulin Aspart (Rapid-acting insulin) and Olanzapine (Atypical antipsychotic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Insulin Aspart is a rapid-acting insulin and Olanzapine is a atypical antipsychotic; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Insulin Aspart and Olanzapine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Drugs That May Decrease the Blood Glucose Lowering Effect of NOVOLOG Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Source: FDA structured product labeling (set_id 13891e5a-e57a-46e8-911c-2f680352b52b).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Insulin Aspart and Olanzapine together?
Insulin Aspart and Olanzapine have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Insulin Aspart and Olanzapine interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: may decrease). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Insulin Aspart and Olanzapine?
If you have been prescribed both Insulin Aspart and Olanzapine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Insulin Aspart Interactions
Other Olanzapine Interactions
- Olanzapine + Fluoxetine(contraindicated)
- Olanzapine + Lithium(contraindicated)
- Olanzapine + Valproic Acid(contraindicated)
- Olanzapine + Carbamazepine(moderate)
- Olanzapine + Diazepam(moderate)
- Olanzapine + Glimepiride(moderate)
- Olanzapine + Insulin Glargine(moderate)
- Olanzapine + Carbidopa Levodopa(minor)
- Olanzapine + Eszopiclone(minor)
- Olanzapine + Omeprazole(minor)
- Olanzapine + Quetiapine(minor)
- Olanzapine + Rifampin(minor)
- Olanzapine + Warfarin(minor)