Does Fluoxetine Interact With Olanzapine?
4 CONTRAINDICATIONS When using fluoxetine capsules and olanzapine in combination, also refer to the Contraindications section of the package insert for Symbyax.
Severity: Contraindicated
Severity basis: contraindications section (keywords: contraindications section). Combining Fluoxetine (SSRI antidepressant) and Olanzapine (Atypical antipsychotic) is classified as a contraindicated interaction.
What to Do
This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Fluoxetine is a ssri antidepressant and Olanzapine is a atypical antipsychotic; together they are documented as a contraindicated interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Fluoxetine and Olanzapine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
4 CONTRAINDICATIONS When using fluoxetine capsules and olanzapine in combination, also refer to the Contraindications section of the package insert for Symbyax.
Source: FDA structured product labeling (set_id 02283de9-6087-45f7-a9ce-3b082ce860de).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Fluoxetine and Olanzapine together?
Fluoxetine and Olanzapine have a documented contraindicated interaction. This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.
How serious is the Fluoxetine and Olanzapine interaction?
It is classified as a contraindicated interaction, based on the FDA label's contraindications section (keywords: contraindications section). A contraindicated pairing generally should not be used together.
What should I do if I'm taking both Fluoxetine and Olanzapine?
If you have been prescribed both Fluoxetine and Olanzapine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Fluoxetine Interactions
- Fluoxetine + Aspirin(major)
- Fluoxetine + Warfarin(major)
- Fluoxetine + Alprazolam(moderate)
- Fluoxetine + Aripiprazole(moderate)
- Fluoxetine + Atomoxetine(moderate)
- Fluoxetine + Buspirone(moderate)
- Fluoxetine + Carbamazepine(moderate)
- Fluoxetine + Diazepam(moderate)
- Fluoxetine + Duloxetine(moderate)
- Fluoxetine + Glimepiride(moderate)
- Fluoxetine + Insulin Aspart(moderate)
- Fluoxetine + Insulin Glargine(moderate)
- Fluoxetine + Lithium(moderate)
- Fluoxetine + Phenytoin(moderate)
- Fluoxetine + Tramadol(moderate)
- Fluoxetine + Amiodarone(minor)
- Fluoxetine + Amitriptyline(minor)
- Fluoxetine + Bupropion(minor)
- Fluoxetine + Carvedilol(minor)
- Fluoxetine + Clonazepam(minor)
- Fluoxetine + Codeine(minor)
- Fluoxetine + Ketoconazole(minor)
- Fluoxetine + Metoprolol(minor)
- Fluoxetine + Risperidone(minor)
- Fluoxetine + Sertraline(minor)
- Fluoxetine + Tacrolimus(minor)
- Fluoxetine + Venlafaxine(minor)
- Fluoxetine + Zolpidem(minor)
Other Olanzapine Interactions
- Olanzapine + Lithium(contraindicated)
- Olanzapine + Valproic Acid(contraindicated)
- Olanzapine + Carbamazepine(moderate)
- Olanzapine + Diazepam(moderate)
- Olanzapine + Glimepiride(moderate)
- Olanzapine + Insulin Aspart(moderate)
- Olanzapine + Insulin Glargine(moderate)
- Olanzapine + Carbidopa Levodopa(minor)
- Olanzapine + Eszopiclone(minor)
- Olanzapine + Omeprazole(minor)
- Olanzapine + Quetiapine(minor)
- Olanzapine + Rifampin(minor)
- Olanzapine + Warfarin(minor)