Does Olanzapine Interact With Quetiapine?
5.3 Cerebrovascular Adverse Reactions, Including Stroke, in Elderly Patients with Dementia-Related Psychosis In placebo-controlled trials with risperidone, aripiprazole, and olanzapine in elderly subjects with dementia, there was a higher incidence of cerebrovascular adverse reactions (cerebrovascular accidents and transient ischemic attacks) including fatalities compared to placebo-treated subjects.
Severity: Minor
Severity basis: warnings section. Combining Olanzapine (Atypical antipsychotic) and Quetiapine (Atypical antipsychotic) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
5.3 Cerebrovascular Adverse Reactions, Including Stroke, in Elderly Patients with Dementia-Related Psychosis In placebo-controlled trials with risperidone, aripiprazole, and olanzapine in elderly subjects with dementia, there was a higher incidence of cerebrovascular adverse reactions (cerebrovascular accidents and transient ischemic attacks) including fatalities compared to placebo-treated subjects.
Source: FDA structured product labeling (set_id 01261008-5f42-4844-8a65-d4545a67a309).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Olanzapine Interactions
- Olanzapine + Fluoxetine(contraindicated)
- Olanzapine + Lithium(contraindicated)
- Olanzapine + Valproic Acid(contraindicated)
- Olanzapine + Carbamazepine(moderate)
- Olanzapine + Diazepam(moderate)
- Olanzapine + Glimepiride(moderate)
- Olanzapine + Insulin Aspart(moderate)
- Olanzapine + Insulin Glargine(moderate)
- Olanzapine + Carbidopa Levodopa(minor)
- Olanzapine + Eszopiclone(minor)
- Olanzapine + Omeprazole(minor)
- Olanzapine + Rifampin(minor)
- Olanzapine + Warfarin(minor)
Other Quetiapine Interactions
- Quetiapine + Amiodarone(major)
- Quetiapine + Clarithromycin(major)
- Quetiapine + Carbamazepine(moderate)
- Quetiapine + Itraconazole(moderate)
- Quetiapine + Phenytoin(moderate)
- Quetiapine + Aripiprazole(minor)
- Quetiapine + Carbidopa Levodopa(minor)
- Quetiapine + Ketoconazole(minor)
- Quetiapine + Lithium(minor)
- Quetiapine + Rifampin(minor)
- Quetiapine + Risperidone(minor)
- Quetiapine + Valproic Acid(minor)