Does Fluoxetine Interact With Glimepiride?
The following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazo…
Severity: Moderate
Severity basis: drug interactions section (keywords: may increase). Combining Fluoxetine (SSRI antidepressant) and Glimepiride (Sulfonylurea) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Fluoxetine is a ssri antidepressant and Glimepiride is a sulfonylurea; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Fluoxetine and Glimepiride, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
The following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazo…
Source: FDA structured product labeling (set_id 0003458f-352a-46fa-9d99-230daa76ae29).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Fluoxetine and Glimepiride together?
Fluoxetine and Glimepiride have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Fluoxetine and Glimepiride interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: may increase). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Fluoxetine and Glimepiride?
If you have been prescribed both Fluoxetine and Glimepiride, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Fluoxetine Interactions
- Fluoxetine + Olanzapine(contraindicated)
- Fluoxetine + Aspirin(major)
- Fluoxetine + Warfarin(major)
- Fluoxetine + Alprazolam(moderate)
- Fluoxetine + Aripiprazole(moderate)
- Fluoxetine + Atomoxetine(moderate)
- Fluoxetine + Buspirone(moderate)
- Fluoxetine + Carbamazepine(moderate)
- Fluoxetine + Diazepam(moderate)
- Fluoxetine + Duloxetine(moderate)
- Fluoxetine + Insulin Aspart(moderate)
- Fluoxetine + Insulin Glargine(moderate)
- Fluoxetine + Lithium(moderate)
- Fluoxetine + Phenytoin(moderate)
- Fluoxetine + Tramadol(moderate)
- Fluoxetine + Amiodarone(minor)
- Fluoxetine + Amitriptyline(minor)
- Fluoxetine + Bupropion(minor)
- Fluoxetine + Carvedilol(minor)
- Fluoxetine + Clonazepam(minor)
- Fluoxetine + Codeine(minor)
- Fluoxetine + Ketoconazole(minor)
- Fluoxetine + Metoprolol(minor)
- Fluoxetine + Risperidone(minor)
- Fluoxetine + Sertraline(minor)
- Fluoxetine + Tacrolimus(minor)
- Fluoxetine + Venlafaxine(minor)
- Fluoxetine + Zolpidem(minor)