Does Methylphenidate Interact With Risperidone?
Methylphenidate Concomitant use with methylphenidate, when there is change in dosage of either medication, may increase the risk of extrapyramidal symptoms (EPS).
Severity: Moderate
Severity basis: drug interactions section (keywords: may increase). Combining Methylphenidate (CNS stimulant (ADHD)) and Risperidone (Atypical antipsychotic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
Methylphenidate Concomitant use with methylphenidate, when there is change in dosage of either medication, may increase the risk of extrapyramidal symptoms (EPS).
Source: FDA structured product labeling (set_id 03d3b52d-3a7d-4595-84c9-332da6ca9171).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Methylphenidate Interactions
Other Risperidone Interactions
- Risperidone + Amitriptyline(major)
- Risperidone + Carbamazepine(moderate)
- Risperidone + Carbidopa Levodopa(moderate)
- Risperidone + Itraconazole(moderate)
- Risperidone + Bupropion(minor)
- Risperidone + Digoxin(minor)
- Risperidone + Fluoxetine(minor)
- Risperidone + Furosemide(minor)
- Risperidone + Lithium(minor)
- Risperidone + Paroxetine(minor)
- Risperidone + Quetiapine(minor)
- Risperidone + Valproic Acid(minor)
- Risperidone + Venlafaxine(minor)