Does Digoxin Interact With Pantoprazole?
For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ].
Severity: Moderate
Severity basis: warnings section (keywords: monitor, consider). Combining Digoxin (Cardiac glycoside) and Pantoprazole (Proton pump inhibitor) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Digoxin is a cardiac glycoside and Pantoprazole is a proton pump inhibitor; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Digoxin and Pantoprazole, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ].
Source: FDA structured product labeling (set_id 014f9762-6948-46b7-8659-5c89f35ad8bf).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Digoxin and Pantoprazole together?
Digoxin and Pantoprazole have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Digoxin and Pantoprazole interaction?
It is classified as a moderate interaction, based on the FDA label's warnings section (keywords: monitor, consider). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Digoxin and Pantoprazole?
If you have been prescribed both Digoxin and Pantoprazole, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Digoxin Interactions
- Digoxin + Albuterol(moderate)
- Digoxin + Atorvastatin(moderate)
- Digoxin + Carvedilol(moderate)
- Digoxin + Clarithromycin(moderate)
- Digoxin + Itraconazole(moderate)
- Digoxin + Lansoprazole(moderate)
- Digoxin + Phenytoin(moderate)
- Digoxin + Simvastatin(moderate)
- Digoxin + Tamsulosin(moderate)
- Digoxin + Ticagrelor(moderate)
- Digoxin + Trazodone(moderate)
- Digoxin + Verapamil(moderate)
- Digoxin + Alprazolam(minor)
- Digoxin + Amiodarone(minor)
- Digoxin + Azithromycin(minor)
- Digoxin + Canagliflozin(minor)
- Digoxin + Celecoxib(minor)
- Digoxin + Colchicine(minor)
- Digoxin + Cyclosporine(minor)
- Digoxin + Dapagliflozin(minor)
- Digoxin + Diclofenac(minor)
- Digoxin + Dicyclomine(minor)
- Digoxin + Diltiazem(minor)
- Digoxin + Enalapril(minor)
- Digoxin + Esomeprazole(minor)
- Digoxin + Finasteride(minor)
- Digoxin + Hydroxychloroquine(minor)
- Digoxin + Ibuprofen(minor)
- Digoxin + Indomethacin(minor)
- Digoxin + Ketoconazole(minor)
- Digoxin + Levofloxacin(minor)
- Digoxin + Lovastatin(minor)
- Digoxin + Metformin(minor)
- Digoxin + Metoclopramide(minor)
- Digoxin + Montelukast(minor)
- Digoxin + Naproxen(minor)
- Digoxin + Nifedipine(minor)
- Digoxin + Omeprazole(minor)
- Digoxin + Raloxifene(minor)
- Digoxin + Ramipril(minor)
- Digoxin + Rifampin(minor)
- Digoxin + Risperidone(minor)
- Digoxin + Sertraline(minor)
- Digoxin + Spironolactone(minor)
- Digoxin + Sucralfate(minor)
- Digoxin + Sulfasalazine(minor)
- Digoxin + Tadalafil(minor)
- Digoxin + Telmisartan(minor)
- Digoxin + Tramadol(minor)