Does Digoxin Interact With Pantoprazole?

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ].

Severity: Moderate

Severity basis: warnings section (keywords: monitor, consider). Combining Digoxin (Cardiac glycoside) and Pantoprazole (Proton pump inhibitor) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ].

Source: FDA structured product labeling (set_id 014f9762-6948-46b7-8659-5c89f35ad8bf).

Digoxin

Cardiac glycoside

Brands: Lanoxin

View Digoxin safety profile

Pantoprazole

Proton pump inhibitor

Brands: Protonix

View Pantoprazole safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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