Does Digoxin Interact With Trazodone?

Digoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels ( 7 ).

Severity: Moderate

Severity basis: drug interactions section (keywords: monitor). Combining Digoxin (Cardiac glycoside) and Trazodone (Serotonin antagonist/reuptake inhibitor) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Digoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels ( 7 ).

Source: FDA structured product labeling (set_id 007f38e0-653b-43e4-a1c1-b59997b2762a).

Digoxin

Cardiac glycoside

Brands: Lanoxin

View Digoxin safety profile

Trazodone

Serotonin antagonist/reuptake inhibitor

Brands: Desyrel, Oleptro

View Trazodone safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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