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    HomeMedication GuideDrug InteractionsDigoxin + Phenytoin
    Moderate interaction

    Does Digoxin Interact With Phenytoin?

    Phenytoin when given with the combination of fosamprenavir and ritonavir may increase the concentration of amprenavir Calcium channel blockers Nifedipine, nimodipine, nisoldipine, verapamil Other Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine a The effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels is unpredictable 7.3 Drug/Laboratory Test …

    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    Severity: Moderate

    Severity basis: drug interactions section (keywords: may increase). Combining Digoxin (Cardiac glycoside) and Phenytoin (Anticonvulsant) is classified as a moderate interaction.

    What to Do

    Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How This Interaction Works

    Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Digoxin is a cardiac glycoside and Phenytoin is a anticonvulsant; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

    If You Take Both Medications

    If you have been prescribed both Digoxin and Phenytoin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    From the FDA Label

    Phenytoin when given with the combination of fosamprenavir and ritonavir may increase the concentration of amprenavir Calcium channel blockers Nifedipine, nimodipine, nisoldipine, verapamil Other Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine a The effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels is unpredictable 7.3 Drug/Laboratory Test …

    Source: FDA structured product labeling (set_id 035a8d4e-2063-4240-83cb-d7eebcabe301).

    Digoxin

    Cardiac glycoside

    Brands: Lanoxin

    View Digoxin safety profile

    Phenytoin

    Anticonvulsant

    Brands: Dilantin

    View Phenytoin safety profile

    Check these against your full medication list in our free Interaction Checker

    Frequently Asked Questions

    Can you take Digoxin and Phenytoin together?

    Digoxin and Phenytoin have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How serious is the Digoxin and Phenytoin interaction?

    It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: may increase). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.

    What should I do if I'm taking both Digoxin and Phenytoin?

    If you have been prescribed both Digoxin and Phenytoin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Questions About Your Medications?

    A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

    Other Digoxin Interactions

    Other Phenytoin Interactions

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.