Does Digoxin Interact With Naproxen?

Digoxin Clinical Impact: The concomitant use of naproxen with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.

Severity: Minor

Severity basis: drug interactions section. Combining Digoxin (Cardiac glycoside) and Naproxen (Nonsteroidal anti-inflammatory drug (NSAID)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Digoxin Clinical Impact: The concomitant use of naproxen with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.

Source: FDA structured product labeling (set_id 000155a8-709c-44e5-a75f-cd890f3a7caf).

Digoxin

Cardiac glycoside

Brands: Lanoxin

View Digoxin safety profile

Naproxen

Nonsteroidal anti-inflammatory drug (NSAID)

Brands: Aleve, Naprosyn

View Naproxen safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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