Does Propranolol Interact With Verapamil?

There have been reports of significant bradycardia, heart failure, and cardiovascular collapse with concurrent use of verapamil and beta-blockers.

Severity: Minor

Severity basis: drug interactions section. Combining Propranolol (Beta-blocker) and Verapamil (Calcium channel blocker) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

There have been reports of significant bradycardia, heart failure, and cardiovascular collapse with concurrent use of verapamil and beta-blockers.

Source: FDA structured product labeling (set_id 013a485a-4227-46ae-b19f-c550302fcb96).

Propranolol

Beta-blocker

Brands: Inderal

View Propranolol safety profile

Verapamil

Calcium channel blocker

Brands: Calan, Verelan

View Verapamil safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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