Does Fluoxetine Interact With Insulin Aspart?
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics.
Severity: Moderate
Severity basis: drug interactions section (keywords: may increase). Combining Fluoxetine (SSRI antidepressant) and Insulin Aspart (Rapid-acting insulin) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Fluoxetine is a ssri antidepressant and Insulin Aspart is a rapid-acting insulin; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Fluoxetine and Insulin Aspart, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics.
Source: FDA structured product labeling (set_id 13891e5a-e57a-46e8-911c-2f680352b52b).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Fluoxetine and Insulin Aspart together?
Fluoxetine and Insulin Aspart have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Fluoxetine and Insulin Aspart interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: may increase). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Fluoxetine and Insulin Aspart?
If you have been prescribed both Fluoxetine and Insulin Aspart, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Fluoxetine Interactions
- Fluoxetine + Olanzapine(contraindicated)
- Fluoxetine + Aspirin(major)
- Fluoxetine + Warfarin(major)
- Fluoxetine + Alprazolam(moderate)
- Fluoxetine + Aripiprazole(moderate)
- Fluoxetine + Atomoxetine(moderate)
- Fluoxetine + Buspirone(moderate)
- Fluoxetine + Carbamazepine(moderate)
- Fluoxetine + Diazepam(moderate)
- Fluoxetine + Duloxetine(moderate)
- Fluoxetine + Glimepiride(moderate)
- Fluoxetine + Insulin Glargine(moderate)
- Fluoxetine + Lithium(moderate)
- Fluoxetine + Phenytoin(moderate)
- Fluoxetine + Tramadol(moderate)
- Fluoxetine + Amiodarone(minor)
- Fluoxetine + Amitriptyline(minor)
- Fluoxetine + Bupropion(minor)
- Fluoxetine + Carvedilol(minor)
- Fluoxetine + Clonazepam(minor)
- Fluoxetine + Codeine(minor)
- Fluoxetine + Ketoconazole(minor)
- Fluoxetine + Metoprolol(minor)
- Fluoxetine + Risperidone(minor)
- Fluoxetine + Sertraline(minor)
- Fluoxetine + Tacrolimus(minor)
- Fluoxetine + Venlafaxine(minor)
- Fluoxetine + Zolpidem(minor)