Does Amiodarone Interact With Levofloxacin?

Levofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.

Severity: Major

Severity basis: warnings section (keywords: avoid). Combining Amiodarone (Class III antiarrhythmic) and Levofloxacin (Fluoroquinolone antibiotic) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

Levofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.

Source: FDA structured product labeling (set_id 05d179f5-b200-8597-e063-6394a90a10cc).

Amiodarone

Class III antiarrhythmic

Brands: Pacerone, Cordarone

View Amiodarone safety profile

Levofloxacin

Fluoroquinolone antibiotic

Brands: Levaquin

View Levofloxacin safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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