Does Amiodarone Interact With Levofloxacin?
Levofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.
Severity: Major
Severity basis: warnings section (keywords: avoid). Combining Amiodarone (Class III antiarrhythmic) and Levofloxacin (Fluoroquinolone antibiotic) is classified as a major interaction.
What to Do
The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Amiodarone is a class iii antiarrhythmic and Levofloxacin is a fluoroquinolone antibiotic; together they are documented as a major interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Amiodarone and Levofloxacin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Levofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.
Source: FDA structured product labeling (set_id 05d179f5-b200-8597-e063-6394a90a10cc).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Amiodarone and Levofloxacin together?
Amiodarone and Levofloxacin have a documented major interaction. The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.
How serious is the Amiodarone and Levofloxacin interaction?
It is classified as a major interaction, based on the FDA label's warnings section (keywords: avoid). A major interaction can cause serious harm and often calls for a change in therapy or close monitoring.
What should I do if I'm taking both Amiodarone and Levofloxacin?
If you have been prescribed both Amiodarone and Levofloxacin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Amiodarone Interactions
- Amiodarone + Clarithromycin(major)
- Amiodarone + Quetiapine(major)
- Amiodarone + Tizanidine(major)
- Amiodarone + Trazodone(major)
- Amiodarone + Azithromycin(moderate)
- Amiodarone + Carvedilol(moderate)
- Amiodarone + Dabigatran(moderate)
- Amiodarone + Fluconazole(moderate)
- Amiodarone + Lithium(moderate)
- Amiodarone + Lovastatin(moderate)
- Amiodarone + Phenytoin(moderate)
- Amiodarone + Tacrolimus(moderate)
- Amiodarone + Atenolol(minor)
- Amiodarone + Atorvastatin(minor)
- Amiodarone + Citalopram(minor)
- Amiodarone + Clonidine(minor)
- Amiodarone + Codeine(minor)
- Amiodarone + Cyclosporine(minor)
- Amiodarone + Digoxin(minor)
- Amiodarone + Diltiazem(minor)
- Amiodarone + Fluoxetine(minor)
- Amiodarone + Levothyroxine(minor)
- Amiodarone + Liothyronine(minor)
- Amiodarone + Prednisone(minor)
- Amiodarone + Propranolol(minor)
- Amiodarone + Simvastatin(minor)
- Amiodarone + Tramadol(minor)
- Amiodarone + Verapamil(minor)
- Amiodarone + Warfarin(minor)